One study of data for 63,878 hospital admissions to a hospital in Boston, MA, from January 2004 through December 2007, found that patients using PPIs had a 30-percent higher chance of developing hospital-acquired pneumonia. Some researchers suggest that some people are prescribed a PPI without needing one, and that discontinuing use could reduce the risk of infection. PPIs have been linked with an initial bout of Clostridium difficile infection (CDI) and recurrence. Other studies have found no link between low calcium absorption and PPI use. The researchers note that this could be because it was a short-term investigation, lasting only 30 days, or because people who use a PPI may have other risk factors already. One study found no link between intestinal calcium absorption and PPI use in women after menopause. One theory is that PPIs interfere with calcium absorption, which may weaken bones.Īnother is that they impact normal bone recycling by inhibiting proton pumps in the body that are involved in bone creation and remodeling. There is some evidence that long-term use of esomeprazole can increase the chances of hip fracture. Nexium can give rise to some additional problems. It also appears to improve esophageal healing rates, compared with some other leading brands. However, Nexium appears to be more effective than some drugs for more severe symptoms. The effects of Nexium on mild symptoms are comparable to similar drugs. PPIs include Aciphex, Zegerid, Prilosec, Protonix and Prevacid. This is due to NSAIDs’ propensity to produce stomach ulcers Nexium helps prevent their formation. Nexium may be used by patients who are taking nonsteroidal anti-inflammatory drugs ( NSAIDs). Zollinger-Ellison syndrome: A pancreatic tumor overstimulates the production of stomach acid. Gastroesophageal reflux disease (GERD): A chronic condition where stomach acid comes up from the stomach into the esophagus and damages the mucosa, leading to heartburn. Peptic ulcer disease: There is a gap in the lining of the stomach, esophagus, or intestine. Nexium is most commonly used to treat the following conditions:ĭyspepsia, or indigestion: Symptoms include nausea, heartburn, and upper abdominal fullness and pain.
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